How many cars any loco can pull is determined by a number of factors, including make of the loco, make and rolling qualities of the cars, the weight of both locos and cars, the radius of any curves (and the number of curves that the train will be in at any one time) and the presence of any grades.
On a 4'x8' layout, your F-unit
may be able to pull enough cars to stretch completely around the layout, but it won't look very believeable.

I'd suggest a train of 3 or 4 cars at most for a passenger train.
As for picking the proper cars for a '50s layout, this can get pretty complicated. If I'm not mistaken, freight cars have an interchange life of 40 years, so any car with a built date 40 years or less before the time of your layout is a candidate. The built date, usually written in small print on the carside to the right of the door as BLT-10-38 or something similar, indicates that this particular car was built in October, 1938. This car should be suitable for your layout. However, this is where it gets complicated. To the left of the door, in with the small lettering that shows how much the car can carry (CAPY, LD LMT, LT WT) there will be a notation that reads either: NEW 10-38, or a station symbol (set of letters) such as RDG 6-54. The "NEW" means that this car, when new in Oct '38, weighed what the other lettering indicates (LT WT) and can carry the amount indicated by the LD LMT. However, cars had to be re-weighed every so often - this was done to verify the current weight of the car (which may have changed due to repairs or alterations since the last weighing) which will affect how much the car can carry. The station symbol (Reading) indicates where the re-weighing was carried out. So far, so good. However, that re-weigh data could just as easily read RDG 5-68, meaning that the car was last re-weighed in May of 1968. So, while the car may be suitable for your chosen era, the lettering is incorrect. In addition to that, the car may have also been repainted to a newer paint scheme, say in 1963, which makes the car even less correct for your era.
Despite all of this, nothing says that you have to be that fussy. In general, most 40' boxcars, either wood or steel, would've been in use into the '50s. There were also a lot of 50' boxcars in use in this period, but many of the 50'-ers offered are of modern cars in use today. I'd suggest 40' is a good guideline for house cars (boxcars, reefers, stockcars), and 50' for gondolas and flatcars, especially on a 4'x8'. If you're dealing with a reputable hobbyshop, they should be able to advise you on what's suitable and what's not. Or, you can always ask here on the Gauge before you buy something.
Sorry to have gone on so long, but this is the kind of information I would have liked to have had when I started out. Just take what's useful to you, and your interests, and have some fun.
Wayne