Yes, I agree. There are so many first-time layouts where the track religiously follows the outer line of the benchwork... try to have some small amount of flexibility in the track position and direction... and of course the first thing to do is to stop using that software and use software that works well with flextrack, allowing you to create nice gentle sweeping curves. Xtrkcad is free nowadays, which a lot of people seem to use (although I haven't).
Do you need double-track all the way through? The layout is starting to look big enough to have a story -- a town at one end and another or some industries at the other end -- dropping to single-track in between would add interest and remove the forced symmetry. Try to think of the design in a 'real-world' sense -- i.e. scenery first, place the towns and industries or harbours or whatever, and then design a railroad that would service the industries (you can then cheat by taking the return from one end round to the start of the other end, pretending that they both are continuations of the track rather than connections to each other).
How many people will be operating the trains? One? Two or more? Think of where they'll stand and what they'll want to be doing, without getting in each others' way...
Charles