This is actually the biggest roster I've ever had available on a fantasy league.
I'll have to wait 3-4 weeks before I really make up my mind, but it seems a bit excessive. (The switch to Fox Sports is also slowing me down a bit, so that's a small factor)
I am used to rosters such as the following:
2 QB Quarterback
2 RB Running back
3 WR Wide receiver
1 TE Tight end
0 R/w Running back or Wide receiver
0 W/T Wide receiver or Tight end
1 PK Place Kicker
2 Def/ST Defense and special teams
4 BN Bench (Sometimes 6)
The smaller roster makes you think twice, thrice, and more before starting a player. You also learn to only rely on consistent players, rather than hope that your star will have an explosive day to make up for last week's let-down. (But it is still worth keeping those players around and using them when you think they'll produce the numbers)
Oh.... and byes become VERY interesting. If you don't plan ahead a bit, you can end up like I did last year. I had 6 of 11 starters on a bye for week 7!
I see the larger roster as a big cushion to give you a reliable 'average' from week to week. With so many players, it's hard to have huge performance swings unless you provoke it with roster changes.
As I said, I still need to make up my mind. I was just throwing that out so you understand any future outbursts I may make, regarding the large roster.

Who know I may like it...
Good luck, and let the best Mallet win!