You will find a billion topics on this, and as someone stated in another thread, you won't get an honest answer from a small percentage of modelers that visit The Gauge.
Personally, as that's the only person I can vouch for (myself), it's definately worth it, on any layout size. Once you go... DCC... you never go back.
For layouts of any size, the flexibility that DCC offers in running trains is crazy. Granted, you have to put a little effort into upgrading your fleet (if you already have one) with decoders, and spend a bit more when purchasing locomotives. But you'll love it.
I have a 4'x7' foot layout, and DCC, even a basic system like Atlas', allows me to run all the locomotives I have room for, and no special wiring such as blocks.
I would imagine starting out with DCC from the get-go would be more convienent than turning back to it later, but I can't say.
Good luck, and happy railroading.
