For an island-type 6x10, there are really only a few good options.
1) Blow up a good 4x8 plan, substituting 22" radius curves for the 18" usually found.
2) There are a few good 6x10 plans out there. Dec '64 through most of 1965, Model Railroader did a progressive 6x10 project railroad called the Ma and Pa. They started out with a simple oval and a few spurs and ended up with quite a layout ( a loop-to-loop with contiuous run). I probably would have stopped before they did, but that's really an individual choice. Lots of how-tos in the series, and again, you can stop expanding the trackwork anytime you like. Flex track with 22" radius curves and Atlas #4 (really 4.5) turnouts were used. Most MRs tend to be reasonably happy with the Atlas Custom-Line turnouts, but other brands of your choice could be substituted.
Thinking inside the box instead of outside, a 6x10 with a center operating pit (accessible by a swinging or hinged section or narrow duck-under) would give a totally different perspective. You would be looking at the trains from inside the curve instead of outside, which generally looks much better. Also, you could possibly expand to where your aisles around the 6x10 would be, making your layout even more sweeping.
A water wings or U shape could also be worked into a 6x10 space if you can tolerate a 24" wide aisle.
The Atlas published plans tend to fall short on switching opportunities and a convincing scenic theme, but long on watching trains roll. I strongly recommend you think about what your vision for your layout is, and what kind of operation you would likely most enjoy. Present those on the forum as your "druthers" and your space (and other hard restrictions) as your "givens", and the design experts can help you design the layout you will be happy with (and not want to tear up as soon as it's built) for years to come. Search through the track planning threads for more ideas, particularly this one:
http://www.the-gauge.com/showthread.php?t=19575. Then use those creative juices to satisfy yourself, and share your discoveries. We'll be cheering you on!
yours in planning