nice looking plan!
tips...hmm...
first off...the space between the pier and the right side of the layout is too small.
if you can, move the pier over to the left.
or tilt it leftish, instead of rightish. (moving the 3 track yard that comes back over to the right side might help)
or best...a combo of both.
this way you'll have more room on the right side to be able to reach the loop in the far corner.
second...check the grade in the loop on the left side.
seems to me you will need a 3% grade. make sure this is acceptable.
third...kinda goes with the above, but is more for cosmetic/aesthetics.
if you stretch the loop out higher, you can have the bridge (red) angle down and across the layout, instead of going straight across. i think this will look nicer.
fourth...have some crossovers between the two mainlines.
lastly...throw in some spurs off the mainline...and have some industries there.
this way, you can route freight and goods between the port and the industries.